Federal grants for small business

Open federal funding opportunities for for-profit companies, startups, and sole proprietors. Sorted by closing date, so the ones running out appear first.

649 open opportunities

Closes Nov 19, 2026

Seamless Early-Stage Clinical Drug Development (Phase 1 to 2a) for Novel therapeutic Agents for the Spectrum of Alzheimer's Disease (AD) and AD-related Dementias (ADRD) (UG3/UH3 Clinical Trial Required)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Oct 19, 2026

Community Engagement Evaluation and Data Coordination (CEED) Hub to Advance Data and Practice Transformation for Optimizing Oral Health for All (U01, Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline$0

Pilot Testing, Implementation, and Evaluation of the Cervical, Breast and Colorectal Cancer Clinical Decision Support Tools

Agency: Centers for Disease Control and Prevention - ERA
Eligible locations: Nationwide

Closes May 7, 2027

Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

23 days left

Substance Use/Substance Use Disorder Dissertation Research Award (R36 Clinical Trials Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Intervention Research to Improve Native American Health

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Apr 28, 2027

NHLBI Emerging Investigator Award (EIA) (R35 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Childhood Asthma in Urban Settings Clinical Research Network

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline$0

Statewide Perinatal Quality Collaboratives: Improving Perinatal Care and Outcomes

Agency: Centers for Disease Control - NCCDPHP
Eligible locations: Nationwide

No stated deadline$500K – $1.2M

Partnership with Common Fund Data Ecosystem Resources

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Sep 25, 2026

Utilizing Equipment to Study Environmental Extrinsic Factors and Enhance Rigor and Reproducibility of Animal Research (R24, Clinical Trials Not-Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Oct 1, 2026

HEAL INITIATIVE: INTERACT Data Coordination and Integration Center (U24 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Precision Approaches in Radiation Synthetic Combinations (PAIRS, RP1 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Jan 7, 2028

NIH Research Project Grant (Parent R01 Clinical Trial Required)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

BRAIN Initiative: Data Archives for the BRAIN Initiative

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Small Business Transition Grant for New Entrepreneurs (Parent R41/R42 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Jan 7, 2028

Innovative Mental Health Services Research Not Involving Clinical Trials (R01 Clinical Trials Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes May 7, 2027

Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

23 days left

Alcohol Treatment, Pharmacotherapy, and Recovery Research (R34 Clinical Trial required)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Sep 25, 2026

NHLBI Program Project Applications (P01 Clinical Trials Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline$3.5M – $22M

Centers of Excellence in Healthcare Quality and Safety

Agency: Centers for Disease Control - NCEZID
Eligible locations: Nationwide

No stated deadline

Global Brain and Nervous System Disorders Research Across the Lifespan - Exploratory Grants

Agency: National Institutes of Health
Eligible locations: Nationwide

2 days left$13.5K – $450K

Title V Competitive Sexual Risk Avoidance Education

Agency: Administration for Children & Families - ACYF/FYSB
Eligible locations: Nationwide

No stated deadline$750K – $1.1M

Continuation and Expansion of the National Mesothelioma Virtual Bank for Translational Research (U24)

Agency: Centers for Disease Control and Prevention - ERA
Eligible locations: Nationwide

No stated deadline$850K – $1.1M

Expanded Surveillance for Pediatric Infectious Diseases

Agency: Centers for Disease Control and Prevention - ERA
Eligible locations: Nationwide