Federal grants for small business

Open federal funding opportunities for for-profit companies, startups, and sole proprietors. Sorted by closing date, so the ones running out appear first.

649 open opportunities

Closes Jan 7, 2028

Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R01 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Sep 7, 2027

Interventions to Reduce Sleep Health Disparities (R01 - Clinical Trials Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadlineUp to $2M

Silvio O. Conte Centers for Basic Neuroscience or Translational Mental Health Research

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes May 7, 2027

Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Required)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadlineUp to $1.5M

Network of the National Library of Medicine Coordinating Center (U24 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline$1M

Cooperative Agreement to Support Effective Dissemination of Clinical Practice Guidelines

Agency: Food and Drug Administration
Eligible locations: Nationwide

No stated deadline

BRAIN Initiative: Brain-Behavior Quantification and Synchronization – Transformative Research on Behavior at the Organismal Level

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline$0 – $20K

NIOSH Support for Conferences and Scientific Meetings (R13 Clinical Trial Not Allowed)

Agency: Centers for Disease Control and Prevention - ERA
Eligible locations: Nationwide

Closes Jan 26, 2029$25K – $250K

Limited Competition: Instrumentation Grant Program for Resource-Limited Institutions (S10 - Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Oct 20, 2027Up to $750K

Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Development and Validation of Model Systems to Facilitate Neurotherapeutic Discovery (R61/R33 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Jan 7, 2028

Mood and Psychosis Symptoms during the Menopause Transition (R21 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Jul 12, 2027

NHLBI Career Transition Award for Intramural Postdoctoral Fellows and Research Trainees (K22 Independent Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Oct 25, 2027

Cancer Prevention and Control Clinical Trials Planning Grant Program (R34 Clinical Trials Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

23 days left

Social disconnection and Suicide Risk in Late Life (R21 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Nov 10, 2026Up to $300K

Advanced Development and Validation of Emerging Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes May 7, 2028

Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

NIDDK Multi-Purpose Resource-Related, Multi-Component Research Services Centers Cooperative Agreement (U2C - Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline$0 – $200K

Ryan White HIV/AIDS Program Part D - Women, Infants, Children and Youth Grant Supplemental Funding

Agency: Health Resources and Services Administration
Eligible locations: Nationwide

Closes Sep 18, 2026

NCI Community Oncology Research Program (NCORP) Academic Community Sites (UG1 Clinical Trials Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Clinical and Translational Science Award

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Limited Competition: Stimulating Access to Research in Residency Transition Scholar (StARRTS)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

HEAL Initiative: Integrative Management of Chronic Pain and Opioid Use Disorder (OUD) for Whole Recovery: Health Systems

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Mar 10, 2027Up to $500K

Continuation of the Cardiovascular Repository for-Type 1 Diabetes (CARE-T1D) Consortium U01 (Open Competition)- Research (U01, Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

23 days left

Cellular and Molecular Biology of Complex Brain Disorders (R21 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Jan 11, 2027

Discovery of the Genetic Basis of Childhood Cancers and of Congenital Anomalies: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide