Federal grants for small business

Open federal funding opportunities for for-profit companies, startups, and sole proprietors. Sorted by closing date, so the ones running out appear first.

649 open opportunities

Closes Dec 23, 2027

Catalyze: Product Definition for Small Molecules, Biologics, and Combination Products - Preliminary Product/Lead Series Identification and Combination Product Prototype (R33 - Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Jan 27, 2027Up to $1M

Diabetes Research Centers (P30 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadlineUp to $1.2M

NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Oct 14, 2026

NCI Pathway to Independence Award for Early-Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Required)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Sep 26, 2028

Animal and Biological Material Resource Centers (P40 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Jan 7, 2028

Mechanisms that Impact Cancer Risk after Bariatric Surgery (R21 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Single Source for Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium - Data Coordinating Center (DCC)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes May 7, 2028Up to $500K

Community-Partnered Nursing Research Centers (P20 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Forecast to Publish a Funding Opportunity Announcement for Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia (U01 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes May 25, 2029

NIAID Investigator Initiated Program Project Applications (P01 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Cooperative Centers of Excellence in Hematology (CCEHs)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Nov 16, 2026Up to $50K

Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

NIDCD Research Fellowship for Audiologists

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Nov 13, 2026Up to $350K

NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required)

Agency: National Institutes of Health
Eligible locations: Nationwide

9 days left$650K

Community Services Block Grant (CSBG) Performance Management, Data Collection, and Compliance Support

Agency: Administration for Children and Families - OCS
Eligible locations: Nationwide

Closes Jan 7, 2027

Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R01 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Alzheimer's Clinical Trials Consortium (ACTC) Clinical Trials

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadlineUp to $4.5M

NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens

Agency: Food and Drug Administration
Eligible locations: Nationwide

Closes Nov 2, 2026

Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61 Clinical Trial Required)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadlineUp to $50K

Toolkits for Dissemination of Genomic Technologies

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline$150K – $400K

Early Detection, Response, and Control of Global Rabies Outbreaks and Associated Threats to America's Dog-Rabies Free Status

Agency: Centers for Disease Control and Prevention - ERA
Eligible locations: Nationwide

No stated deadline

Autism Centers of Excellence P50

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline$0

Strengthening Services to Prevent the Infectious Disease Consequences of Drug Use

Agency: Centers for Disease Control - NCHHSTP
Eligible locations: Nationwide

Closes May 4, 2028

Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)

Agency: National Institutes of Health
Eligible locations: Nationwide