Federal grants for small business

Open federal funding opportunities for for-profit companies, startups, and sole proprietors. Sorted by closing date, so the ones running out appear first.

652 open opportunities

Closes May 7, 2028

Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions with NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline$300K

Synthesis and Biological Activity Assessment of Different Diastereomers in siRNA Drug LEQVIO (Inclisiran) (U01) Clinical Trial Not Allowed

Agency: Food and Drug Administration
Eligible locations: Nationwide

Closes Oct 19, 2026

PRIMED-AI: Data-to-Model Academic-Industrial Partnerships (D2M-AIP) for Precision Medicine with AI: Integrating Imaging with Multimodal Data (UG3/UH3 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

NIH Research Program Projects (Parent P01 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Enhancement and Management of Established Biomedical Data Repositories and Knowledgebases (R24 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Forecast for NINDS Exploratory Grant Program in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Research (P20 - Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Assay Development and Therapeutic Agent Identification

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Palliative Care Research Across the Lifespan: Leveraging the Palliative Care Consortium

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Notice of Intent to Publish a Funding Opportunity Announcement for Trailblazer Award for New and Early-Stage Investigators (R21 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadlineUp to $6M

Notice of Intent to Publish a Funding Opportunity Announcement for Single Source for Continuation of the Environmental Determinants of Diabetes in The Young Study (TEDDY) Data Coordinating Center (U01 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Nov 2, 2026

Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Oct 2, 2026Up to $2M

Validation Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U54 Clinical Trials Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadlineFrom $850K

Comprehensive Partnerships to Advance Cancer Health (CPACH) (U54 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Nov 17, 2026

Prevention and Intervention Approaches for Fetal Alcohol Spectrum Disorders (R61/R33 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

4 days left

Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development of Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Sep 25, 2027

NICHD Resource Program Grants in Bioinformatics (P41 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

NIEHS Worker Training Program’s SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Limited Competition: Small Grant Program for the NCATS Clinical and Translational Science Award (CTSA) Program (Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Grants for Early Medical/Surgical Specialists' Transition to Aging Research (GEMSSTAR)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Oct 19, 2026$50K – $600K

Sustained Support for Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Oct 15, 2026

Advancing Research on Empirically-Supported Interventions for Older Adults Living with Serious Mental Illness (SMI) (R01 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

INCLUDE Project: Omics Phenotypes Related to Down Syndrome (X01 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline$0 – $1.2M

CDC National Centers of Excellence in Youth Violence Prevention (YVPCs): Rigorous Evaluation of Prevention Approaches to Prevent and Reduce Youth Violence

Agency: Centers for Disease Control and Prevention - ERA
Eligible locations: Nationwide

No stated deadline

Genomic and Biologic Therapies for ADRD (U01 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide