Open federal grants available in South Dakota

Currently open U.S. federal opportunities that South Dakota applicants can apply for, including nationwide programs. Sorted by closing date. Applications are submitted on Grants.gov.

1,638 open opportunities

Closes Oct 1, 2026

Limited Competition: Growing Great Ideas: Research Education Course in Entrepreneurship and Product Development for Researchers Studying Drug Use, Drug Misuse, and Drug Addiction (UE5 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Oct 9, 2026$1 – $60M

FYs 2024 through 2026 - Promoting Resilient Operations for Transformative, Efficient, and Cost-saving Transportation (PROTECT) Competitive Grant Program Notice of Funding Opportunity

Agency: DOT Federal Highway Administration
Eligible locations: Nationwide

21 days left$1 – $400K

Plant Protection Act Section 7721 Plant Pest and Disease Management and Disaster Prevention Program (PPDMDPP)

Agency: Animal and Plant Health Inspection Service
Eligible locations: Nationwide

No stated deadline

ancient DNA for Modern Genomics (aDMG) Coordination Center

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Oct 30, 2026

GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Implementation Science to End the HIV Epidemic

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Aug 16, 2027$200K – $2M

Chemical Oceanography

Agency: U.S. National Science Foundation
Eligible locations: Nationwide

Closes Aug 17, 2076From $300K

MPS Mathematical Sciences Research Programs (MPS MathSci)

Agency: U.S. National Science Foundation
Eligible locations: Nationwide

No stated deadlineFrom $250K

NIAMS Clinical Trial Implementation Cooperative Agreement

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline$1M – $5M

Preservation and Reinvestment Initiative for Community Enhancement (PRICE)

Agency: Department of Housing and Urban Development
Eligible locations: Nationwide

Closes Oct 16, 2026

Strengthening Ghana Health Service laboratory services, diagnostic networks, and systems for a more effective, efficient, and sustainable response to HIV, TB, and other priority health threats

Agency: Centers for Disease Control-GHC
Eligible locations: Nationwide

Closes Oct 6, 2026$1.5M

OVW Fiscal Year 2026 Electronic Service Protection Order Court Pilot Program

Agency: Office on Violence Against Women
Eligible locations: Nationwide

Closes Nov 19, 2026

DoW Toxic Exposures Clinical Trial Award

Agency: Defense Health Agency Contracting Activity - DHACA
Eligible locations: Nationwide

Closes Jul 12, 2027

Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide
Assistance listing number: ALN 93.865

Closes Oct 19, 2027

Early-Stage Development of Informatics Technologies for Cancer Research and Management (U01 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

RFI - DOE Infrastructure Work Scope Development

Agency: Idaho Field Office
Eligible locations: Nationwide

No stated deadline

The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) Genomic Research Centers

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes May 7, 2027

Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide
Assistance listing number: ALN 93.865

8 days left$2M – $3M

U.S. National Science Foundation Research Traineeship (NRT) Program

Agency: U.S. National Science Foundation
Eligible locations: Nationwide

Closes Oct 8, 2027

Translational Efforts to Advance Gene-based Therapies for Ultra-Rare Neurological and Neuromuscular Disorders (U01 - Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

18 days left$50K – $1M

F26AS00051_FY 2026 Competitive State Wildlife Grant (C-SWG) Program_Funding Opportunity Announcement

Agency: Fish and Wildlife Service
Eligible locations: Nationwide
Assistance listing number: ALN 15.634

Closes Jun 2, 2027

Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Manufacturing Systems Integration (MSI)

Agency: U.S. National Science Foundation
Eligible locations: Nationwide

18 days left$300K – $500K

Trauma Care Readiness and Coordination Cooperative Agreement

Agency: Assistant Secretary for Preparedness and Response
Eligible locations: Nationwide

Closes Jul 5, 2029Up to $500K

NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement (U01 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide