Federal grants for small business

Open federal funding opportunities for for-profit companies, startups, and sole proprietors. Sorted by closing date, so the ones running out appear first.

652 open opportunities

Closes Dec 23, 2027

Catalyze: Product Definition for Small Molecules, Biologics and Combination Products - Target Identification and Validation, and Preliminary Product/Lead Series Identification (R61/R33 Clinical Trials Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Jan 7, 2027

Cancer Prevention and Control Clinical Trials Grant Program (R01 Clinical Trial Required)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Controlled Clinical Trials on Long-Term Effects of Nutritional Interventions on the Progression of Risk Factors for Age-Related Chronic Conditions Over the Life Span and Their Age of Onset

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Jun 7, 2028

Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

BRAIN Initiative: Development and Validation of Novel Tools and New Approaches for Neuroscience Research

Agency: National Institutes of Health
Eligible locations: Nationwide

12 days left$1.5M – $2.2M

Collaborative Approaches to Adoption for Children with Complex Needs

Agency: Administration for Children and Families - ACYF/CB
Eligible locations: Nationwide

Closes Mar 6, 2027

High Priority HIV and Substance Use Research (R01 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Forecast to Publish a Notice of Funding Opportunity for SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Oct 18, 2027

NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders (U01 - Clinical Trial Required)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes May 8, 2028

NHLBI TOPMed: Omics Phenotypes of Heart, Lung, and Blood Disorders (X01 - Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Applied regulatory science research to evaluate and treat cardiotoxicity of oncology therapeutics

Agency: Food and Drug Administration
Eligible locations: Nationwide

No stated deadline

Interdisciplinary Research to Understand the Complex Biology of Resilience to Alzheimer’s and Related Dementias Disease Risk

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Sep 30, 2026$5K – $8M

Advanced Nuclear Energy Licensing Cost-Share Grant Program

Agency: Idaho Field Office
Eligible locations: Nationwide

Closes Jan 6, 2028

Continuation or Revision of NIDCR Clinical Trial Planning and Implementation Cooperative Agreement (UH3 Clinical Trial Required)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes May 7, 2027

NIDCD Research Career Enhancement Award for Established Investigators (K18 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

Dental Primary Care Practice-Based Research Network: Clinical Trial or Observational Study Planning and Implementation Cooperative Agreement

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Jan 7, 2027

Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

Closes Jun 15, 2028

INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline$650K – $900K

Clinical Trials Addressing Unmet Needs of Rare Neurodegenerative Diseases (R01) Clinical Trials Required

Agency: Food and Drug Administration
Eligible locations: Nationwide

Closes Dec 3, 2027

Accelerating the Pace of Substance Use Research Using Existing Data (R01 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadlineUp to $150K

Early-Stage Innovative Technology Development for Basic and Clinical Cancer Research (R61 Clinical Trial Not Allowed)

Agency: National Institutes of Health
Eligible locations: Nationwide

No stated deadline

HEAL Initiative: Pain Management Effectiveness Research Network: Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

Agency: National Institutes of Health
Eligible locations: Nationwide

24 days left

Schizophrenia and related disorders during mid- to late-life (R01 Clinical Trial Optional)

Agency: National Institutes of Health
Eligible locations: Nationwide

17 days left$2.7M – $2.9M

National Research Center for Promoting Work and Strong Families

Agency: Administration for Children and Families - OFA
Eligible locations: Nationwide

No stated deadline

The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) Data Coordinating Center

Agency: National Institutes of Health
Eligible locations: Nationwide